Recent versions of DisplayPort include the ability to split to multiple displays from one DisplayPort connection using Multi-Stream Transport (MST).
Although you will be able to connect the MST hub to the Mini DisplayPort (mDP) connection on your Mac, Mac OSX does not support MST for NVIDIA and Intel Graphics Processor Units (GPUs). This results in a mirrored image across the outputs of a MST hub and you will not be able to have multiple independent displays on your Mac.
The limitation of NVIDIA and Intel GPUs lies within Mac OSX. If a different operating system is used, such as Microsoft Windows via Bootcamp, you may be able to use the MST functionality of your Mac.